FREE prescription evaluation Call Us Now (800) 360-0279

Open/Close Menu Valuecare is a specialty workers compensation pharmacy & auto injury compounding pharmacy.We accept prescriptions under workers compensation no-fault
Evaluation of the Percutaneous Absorption of Ketamine HCl, Gabapentin, Clonidine HCl, and Baclofen, in Compounded Transdermal Pain Formulations, Using the Franz Finite Dose Model.

Evaluation of the Percutaneous Absorption of Ketamine HCl, Gabapentin, Clonidine HCl, and Baclofen, in Compounded Transdermal Pain Formulations, Using the Franz Finite Dose Model.
Abstract
OBJECTIVE
This study evaluates the ability of four commonly used analgesics (ketamine HCl, gabapentin, clonidine HCl, and baclofen), when incorporated into two transdermal compounding bases, Lipoderm and Lipoderm ActiveMax, to penetrate human cadaver trunk skin in vitro, using the Franz finite dose model.
DESIGN
In vitro experimental study. Methods. Ketamine HCl 5% w/w, gabapentin 10% w/w, clonidine HCl 0.2% w/w, and baclofen 2% w/w were compounded into two transdermal bases, Lipoderm and Lipoderm ActiveMax. Each compounded drug formulation was tested on the skin from three different donors and three replicate skin sections per donor. The Franz finite dose model was used in this study to evaluate the percutaneous absorption and distribution of drugs within each formulation.
RESULTS
Rapid penetration to peak flux was detected for gabapentin and baclofen at approximately 1 hour after application. Clonidine HCl also had a rapid penetration to peak flux occurring approximately 1 hour after application and had a secondary peak at approximately 40 hours. Ketamine HCl exhibited higher overall absorption rates than the other drugs and peaked at 6–10 hours. Similar patterns of drug distribution within the skin were also observed using both transdermal bases.
CONCLUSIONS
This study suggests that the combination of these 4 analgesic drugs can be successfully delivered transdermally, using either Lipoderm or Lipoderm ActiveMax. Compounded Transdermal drug preparations may then provide physicians with an alternative to traditional oral pain management regimens that can be personalized to the specific patient with the potential for enhanced pain control.

Write a comment:

*

Your email address will not be published.

All trademarks, brands, logos and copyright images are the property of their respective owners and rights holders and are used solely to represent the products of these rights holders. DISCLAIMER OF ENDORSEMENT: Reference to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise [including links to other sites] does not necessarily constitute or imply its endorsement, recommendation, or favoring by this site Valuecare Pharmacy Inc., or by any agents/agencies/associates thereof. Similarly, reference to any specific commercial product, process, service, or individual by name, trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply their endorsement, recommendation, or favoring of this site Valuecare Pharmacy Inc., or any products/services offered on or by this site. The views and opinions of document authors do not necessarily state or reflect those of this site Valuecare Pharmacy Inc., or any agents thereof. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Valuecare Pharmacy Inc. is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. Valuecare Pharmacy Inc. provides no warranty for any of the pricing data or other information. Please seek medical advice before starting, changing or terminating any medical treatment. 2018 © Copyright  | Privacy Policy | Terms of ServiceNew Jersey Workers CompFlorida Workers CompNew York Workers CompPennsylvania Workers Comp

For emergency cases    

CALL ME
+
Call me!